Home > Specialties > Reagents, Molecular Assay, Gene Anomaly, Mutation, VKORC1

Reagents, Molecular Assay, Gene Anomaly, Mutation, VKORC1

Definition : Molecular assay reagents intended to identify mutations in the vitamin K epoxide reductase complex, subunit 1 gene, located at chromosome 16p11.2, which encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. Mutations at this locus, such as the presence of the sensitive AA genotype, can be associated with a high sensitivity to the effects of warfarin; on the contrary, the presence of a GG genotype usually is associated with a high resistance to the effects of warfarin.

Entry Terms : "VKORC1 Gene Mutation Detection Reagents" , "Warfarin Dose Determination Reagents"

UMDC code : 26997


1-1 of 1 Match(es).

Idaho Technology Inc

The Company currently holds over 70 patents related to polymerase chain reaction (PCR), including rapid PCR cycling. The Company has used its extensive patent portfolio to successfully market nearly 200 products to the clinical, research and military markets. The Company manufactures and distributes its proprietary diagnostic respiratory panel, FilmArray RP, which operates on its user-friendly FilmArray system, to hospital-based clinical laboratories in the U.S. and E.U.

1-1 of 1 Match(es).


Medical Product Guide Optometric Management Product Guide