Home > Specialties > Reagents, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG, FMR1 Gene

Reagents, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG, FMR1 Gene

Definition : Molecular assay reagents intended to identify CGG repeats in the fragile X mental retardation 1 (FMR1) gene, located at chromosome Xq27.3. Normal alleles have from10 to 40 CGG trinucleotide repeats and are typically interrupted by AGG trinucleotide repeats. A variation from the expected number of normal CGG trinucleotide repeat copies may produce altered DNA and improper gene functioning, resulting in full mutation. Alleles with from 200 to 1,000 CGG trinucleotide repeats have been associated with fragile X-associated mental retardation (FRAXE). Alleles with from 55 to 200 CGG repeats have been associated with fragile X-associated tremor/ataxia syndrome (FXTAS). Women that have alleles with from 35 to 54 CGG trinucleotide repeats have an increased risk of developing premature ovarian failure.

Entry Terms : "FMR1-Related Premature Ovarian Failure Gene Mutation Reagents" , "Premature Ovarian Failure (POF) Disease Gene Mutation Reagents" , "Fragile X- Tremor/Ataxia Syndrome (FXTAS) Gene Mutation Reagents" , "Fragile X Syndrome Gene Mutation Reagents" , "FMR1 Gene Mutation Detection Reagents, CGG Trinucleotide Repeats" , "Reagents, Molecular Assay, Inborn Disorder, Monogenic, Fragile X Syndrome"

UMDC code : 25032


1-7 of 7 Match(es).

Applied Biosystems

Our newly expanded portfolio of market-leading lab services can provide your high-performance lab with a comprehensive suite of services, or just the ones you want. From business consulting and protocol development, to instrument repair and optimization, our services can help you increase your lab's productivity and efficiency.

Focus Diagnostics Inc

As part of the Quest Diagnostics family, Focus Diagnostics, Inc. is committed to providing proven and reliable products its customers have grown accustomed to throughout the years. Since its founding in 1978, Focus Diagnostics has grown its business from specialized laboratory testing to manufacturing its high-quality laboratory tests for hospitals and commercial laboratories worldwide. These manufactured tests are built in response to diagnostic testing trends identified and evaluated by Focus Diagnostics and used in Quest Diagnostics' national laboratories.

Gen-Probe Inc

Gen-Probe is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective molecular diagnostic products and services that are used primarily to diagnose human diseases, screen donated human blood, and ensure transplant compatibility.

Gen-Probe Life Sciences Ltd

Gen-Probe Life Sciences Ltd

HyTest Ltd

HyTest Ltd

Innogenetics Inc

Innogenetics NV is an international diagnostic company that develops and markets diagnostic products to improve therapy management and patient health.


QIAGEN is the leading global provider of sample and assay technologies. Sample technologies are used to isolate and process DNA, RNA, and proteins from biological samples such as blood or tissue. Assay technologies are used to make such isolated biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.

1-7 of 7 Match(es).


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