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Molecular Microarrays, Mutation/Polymorphism

Definition : Microarrays designed to detect mutations or polymorphisms in a gene sequence. The packet samples on the microarray spots typically consist of immobilized DNA from a single gene; the sequence placed on any given spot of the microarray differs from that on other spots by only one or a few specific nucleotides. A sequence that is frequently used follows small single genetic variations that can occur within a human DNA sequence, known as single nucleotide polymorphisms (SNPs). Samples of labeled DNA from a person's normal tissue are hybridized to the array; the sample DNA will hybridize with greater frequency to SNPs particular to that person. If the sample SNP pattern is coincident to the known pattern for a given disease, the person has, or is at risk of having, the disease. Mutation/polymorphism molecular microarrays can be used to screen for inherited or acquired genetic susceptibility to a particular illness and/or other genetic characteristics (e.g., metabolism).

Entry Terms : "Gene Polymorphism Microarrays" , "Gene Mutation Microarrays" , "Single Nucleotide Polymorphism (SNP) Microarrays"

UMDC code : 20819

   

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Affymetrix China

Affymetrix China

Affymetrix Inc

Affymetrix technology is used by the world's top pharmaceutical, diagnostic, and biotechnology companies, as well as leading academic, government, and nonprofit research institutes. More than 25,000 peer-reviewed papers have been published using the technology.

Affymetrix Japan KK

Affymetrix Japan KK

Affymetrix Singapore Pte Ltd

Affymetrix Singapore Pte Ltd

Affymetrix UK Ltd

Affymetrix UK Ltd

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