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IVD Test Reagent/Kits, Immunoassay, Toxicology, Antidepressant

Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine one or more of a group of drugs that stimulates the mood of a depressed patient (i.e., antidepressants). The most frequently administered antidepressants contain three fused rings in their chemical structure (i.e., tricyclic antidepressants). They include amitryptiline, desipramine, doxepin, imipramine, and nortriptyline. Some tetracyclic drugs are also used as antidepressants. Reagents used to determine antidepressant concentration in blood differentiate therapeutic levels (typically very low) from toxic levels due to overdose. Tricyclic antidepressant concentration in serum is directly related to therapeutic response, with the exception of nortriptyline which has a specific therapeutic window (typically 50 to 150 nanograms/milliliter). The metabolism of tricyclic antidepressants, especially their hydroxylation, results in the formation of active metabolites, which contribute to both the therapeutic and the adverse effects of these compounds.

Entry Terms : "Antidepressant Determination Reagents" , "Reagents, Immunoassay, Toxicology, Antidepressant"

UMDC code : 20052

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1-2 of 2 Match(es).

Bio-Rad Laboratories Inc

Company Type: Parent

Bio-Rad Laboratories continues to play a leading role in the advancement of scientific discovery by offering a broad range of innovative tools and services to the life science research and clinical diagnostics markets. Founded in 1952, Bio-Rad has a global team of more than 7,000 employees and serves more than 100,000 research and industry customers worldwide through the company's global network of operations.

Mayo Medical Laboratories

Company Type: Parent

1-2 of 2 Match(es).

 

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