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Sample Preparation Equipment, Laboratory, Mass Spectrometry

Definition : Equipment designed for preparation of samples before mass spectrometry procedures. Most equipment is used for preparation of samples for matrix-assisted laser desorption/deionization (MALDI) mass spectrometry procedures. The equipment may used one of several different types of matrices as well as preparation techniques. The main aim is to obtain a homogenous layer of small matrix crystals containing a solid solution of the analyte. The preparation process is performed in two steps: (1) isolation and purification of a single or a mixture of components free from contaminants, and (2) sample processing in the MALDI target. The process includes the selection of matrix type [e.g., Sinapinic Acid, alpha-Cyano-4-hydroxycinnamic acid ( HCCA)], analyte concentration, crystallization conditions, additives, and in-situ sample cleaning. The methods of sample preparation include wetting the target with appropriate solutions, washing, and drying using a inert gas; the most used methods are the dried droplet method, the thin layer method, and the double layer method.

UMDC code : 34878

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Bruker Daltonics Inc

Company Type: Parent

Right from the beginning, which is now more than fifty years ago, Bruker has been driven by a single idea: to provide the best technological solution for each analytical task. Today, worldwide more than 5400 employees are working on this permanent challenge at over 90 locations on all continents. Bruker systems cover a broad spectrum of applications in all fields of research and development and are used in all industrial production processes for the purpose of ensuring quality and process reliability.

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