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Nucleic Acid Processors, Sequencing

Definition : Nucleic acid processors designed for the automated determination of the precise sequence of the base pairs (i.e., adenine, thymine, cytosine, and guanine for DNA) in a sample of nucleic acid. These devices typically process samples of DNA molecules (labeled with multiple fluorescent dyes) that are loaded onto a gel. Usually, the samples are separated by size using capillary electrophoresis; samples are illuminated and detected using a scanning laser beam, and the results are processed using computer analysis. Electrophoretic separation can be displayed in real time; the sequence of nucleotides for the whole sample (e.g., read lengths as long as several hundred base pairs) is printed after computerized ordering.

Entry Terms : "Nucleic Acid Sequencers" , "DNA Sequencing Systems" , "RNA Sequencers" , "DNA Sequencers"

UMDC code : 20809

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